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Possible Causes Of Miscarriage In The First 8 Weeks

Published on 07/20/25

The first few weeks of pregnancy can be an exciting yet stressful time for expectant parents. For many, the first eight weeks are when key development occurs for both the mother and the fetus. However, this period can also be a delicate stage, as up to 20% of pregnancies end in miscarriage, often before the mother even realizes she’s pregnant. Miscarriage can happen for a variety of reasons, some of which are beyond anyone’s control. It’s important to understand the possible things that can cause a miscarriage in the first 8 weeks so that women can be better informed and prepared.

In this blog post, we will explore some of the most common causes of miscarriage during these critical early weeks, including chromosomal abnormalities, hormonal imbalances, and health conditions that may increase the risk. We will also discuss the implications of multiple miscarriages at 6-8 weeks and why seeking specialized care, such as from a recurrent pregnancy loss specialist, may be the next step for some women.

Chromosomal Abnormalities: The Most Common Cause of Early Miscarriage

One of the primary causes of miscarriage in the first 8 weeks is chromosomal abnormalities. When sperm and egg combine, they each contribute half of the chromosomes needed to create a healthy embryo. Sometimes, the chromosomes do not combine properly, leading to an imbalance that prevents the pregnancy from progressing. These abnormalities are often random and are typically not caused by anything that the mother or father does.

Most of these chromosomal issues are not compatible with life, and the body naturally terminates the pregnancy early to prevent further complications. It is estimated that around 50-70% of early miscarriages occur due to chromosomal abnormalities. These miscarriages often happen early, within the first 6 to 8 weeks of pregnancy, making it one of the most common reasons for miscarriage during this time.

If you’ve experienced multiple miscarriages at 6-8 weeks, chromosomal abnormalities may be a contributing factor. However, it’s important to note that even if chromosomal issues are the cause, they usually do not indicate a problem with the mother’s health or fertility. If you’ve experienced recurrent pregnancy loss, recurrent pregnancy loss specialists can help identify the root causes and offer treatment options.

Uterine Abnormalities and Structural Issues

Another potential cause of miscarriage in the first 8 weeks is a structural abnormality within the uterus. These abnormalities can affect the shape or size of the uterus, which may prevent the embryo from properly implanting or growing. Conditions such as uterine fibroids, an abnormally shaped uterus, or a septum (a wall dividing the uterus) can all contribute to pregnancy loss during the early stages.

Women with these conditions may experience difficulty maintaining a pregnancy, especially in the first trimester. However, not all structural issues necessarily result in miscarriage, and many pregnancy issues can be treated successfully. Some women may undergo surgery to remove fibroids or correct a septum, improving their chances of carrying a pregnancy to term.

It’s also worth noting that some women with uterine abnormalities may not even know they have the condition until they experience multiple miscarriages at 6-8 weeks. A thorough evaluation by a specialist can help determine if a structural issue is contributing to pregnancy loss. At Rosh Maternal & Fetal Medicine, we offer a range of diagnostic tools to identify any uterine abnormalities that may be affecting your fertility and pregnancy health.

Hormonal Imbalances: The Role of Progesterone

Hormonal imbalances can also play a significant role in early pregnancy loss, especially within the first 8 weeks. One of the most important hormones for sustaining early pregnancy is progesterone, which helps prepare the uterus for implantation and supports the early stages of pregnancy.

In some cases, women may have insufficient progesterone production, which can lead to the failure of the embryo to implant or the miscarriage of the pregnancy. Low progesterone levels can occur naturally or as a result of underlying medical conditions such as polycystic ovary syndrome (PCOS) or thyroid disorders.

For women with progesterone issues, hormonal treatments such as progesterone supplementation may help sustain the pregnancy. If you’ve experienced recurrent pregnancy loss due to hormonal imbalances, our specialists can offer tailored treatment plans to correct the imbalance and increase your chances of a healthy pregnancy.

Infections: How They Impact Pregnancy

Certain infections can also increase the risk of miscarriage in the first 8 weeks. While infections such as the flu or a cold typically don’t affect pregnancy, more serious infections, like listeria, rubella (German measles), or sexually transmitted infections (STIs) like chlamydia or gonorrhea, can pose a risk.

These infections can damage the developing embryo or cause complications that prevent the pregnancy from progressing. It’s important for pregnant women to avoid exposure to infections and to follow good hygiene practices to reduce the risk. If you have concerns about infections during pregnancy, it’s important to discuss them with your healthcare provider to prevent complications.

In some cases, women with recurrent pregnancy loss may unknowingly carry infections that impact their ability to carry a pregnancy to term. Rosh Maternal & Fetal Medicine offers diagnostic tests to check for infections that could be contributing to pregnancy loss, allowing for prompt treatment and better outcomes.

Lifestyle Factors and Environmental Exposures

Your lifestyle choices and environment can also impact your pregnancy. Certain habits and exposures may increase the likelihood of miscarriage, especially during the early stages. Smoking, excessive alcohol consumption, and drug use, particularly illicit drugs like cocaine, can all negatively affect pregnancy.

In addition to lifestyle choices, environmental exposures to toxic substances, such as pesticides, chemicals, or radiation, can also increase the risk of miscarriage. Women who work in industries with exposure to harmful chemicals or who live in areas with high levels of pollution may be at greater risk.

Maintaining a healthy lifestyle and avoiding harmful substances can help reduce the risk of early pregnancy loss. If you have concerns about how your environment or lifestyle may be impacting your pregnancy, we recommend seeking advice from one of our specialists.

Age and Reproductive Health: A Key Factor in Miscarriage Risk

As women age, the risk of miscarriage, particularly during the first 8 weeks, tends to increase. This is largely due to a decline in egg quality and quantity. Women over the age of 35 are at higher risk of experiencing chromosomal abnormalities in their eggs, which can lead to miscarriage. The likelihood of miscarriage also increases as a woman gets older due to a decrease in the ovarian reserve.

Women in their 40s are significantly more likely to experience multiple miscarriages at 6-8 weeks due to the natural aging process of eggs. However, it’s important to note that age-related fertility decline varies from person to person. While age is a factor, it’s not the only factor that determines miscarriage risk. Many women over 40 can still conceive and carry a healthy pregnancy to term with the right medical support and care.

Polycystic Ovary Syndrome (PCOS) and Miscarriage Risk

Polycystic ovary syndrome (PCOS) is another common condition that can increase the risk of miscarriage, especially in the first trimester. PCOS affects a woman’s hormonal balance and can lead to irregular menstrual cycles, making it more difficult to conceive. Women with PCOS often have higher levels of insulin, which can disrupt ovulation and egg development.

For women with PCOS, the risk of early pregnancy loss is higher due to hormonal imbalances that can interfere with embryo implantation or the early stages of pregnancy. If you have PCOS and have experienced multiple miscarriages at 6-8 weeks, it may be beneficial to discuss treatment options with a specialist. Medications to regulate hormones and assist with ovulation can improve your chances of a healthy pregnancy.

Blood Clotting Disorders: How They Contribute to Early Pregnancy Loss

Blood clotting disorders, such as antiphospholipid syndrome (APS), also fall under the things that can cause a miscarriage in the first 8 weeks. APS is a condition where the body forms abnormal blood clots, which can disrupt blood flow to the placenta. This condition can cause placental insufficiency, preventing the fetus from receiving the nutrients and oxygen it needs to survive.

Women with APS may experience recurrent miscarriages in the early stages of pregnancy. If you have a history of blood clotting disorders and have suffered multiple miscarriages, it’s important to consult with a recurrent pregnancy loss specialist. Treatment options, including blood thinners or other medications, can be prescribed to reduce the risk of miscarriage in subsequent pregnancies.

What To Do if You’ve Had Multiple Miscarriages at 6-8 Weeks

If you’ve experienced multiple miscarriages at 6-8 weeks, it can be an emotionally challenging time. Recurrent pregnancy loss is defined as having three or more miscarriages in a row, and it can be particularly distressing when they occur early in pregnancy. It’s important to seek support and get the help you need.

At Rosh Maternal & Fetal Medicine, we have specialists who focus on recurrent pregnancy loss and can help uncover the underlying causes of multiple miscarriages. Our team offers advanced testing and a variety of treatment options to increase the chances of a successful pregnancy.

Frequently Asked Questions About Miscarriage in the First 8 Weeks

  • What causes miscarriage in the first 8 weeks of pregnancy?

The most common causes of miscarriage in the first 8 weeks include chromosomal abnormalities, uterine abnormalities, hormonal imbalances, infections, and lifestyle factors such as smoking or excessive alcohol consumption.

  • How can I reduce my risk of miscarriage in the first trimester?

To reduce the risk, avoid smoking, limit alcohol intake, maintain a healthy weight, and manage conditions like diabetes and thyroid disorders. It’s also important to attend regular prenatal check-ups to monitor your health.

  • Can stress cause a miscarriage?

While stress can affect overall health, research does not show a direct link between stress and miscarriage. However, extreme stress may negatively impact your mental and physical health, which can indirectly affect your pregnancy.

  • How can I tell if I am having a miscarriage?

Common signs of miscarriage include vaginal bleeding, abdominal pain or cramping, passing of tissue or clots, and a decrease in pregnancy symptoms like nausea or breast tenderness. If you experience these symptoms, contact your doctor immediately.

  • What should I do if I experience miscarriage symptoms?

If you suspect you’re having a miscarriage, it’s important to contact your doctor as soon as possible. An ultrasound and blood tests may be performed to confirm whether a miscarriage is occurring and determine the next steps.

  • Can I get pregnant again after a miscarriage?

Yes, most women can conceive again after a miscarriage. However, it’s important to give your body time to heal physically and emotionally before trying again. Your doctor can provide guidance on the best timing for conception after a miscarriage.

  • How long should I wait before trying to conceive again after a miscarriage?

After a miscarriage, the timing for trying to conceive again can vary depending on your physical and emotional recovery. Medically, many women are physically capable of trying to conceive as soon as they have had one normal menstrual cycle after a miscarriage. This typically occurs within 4 to 6 weeks. However, it’s important to listen to your body and consider your emotional well-being before trying again.

If you’re physically healthy and feel emotionally ready, trying to conceive sooner may be possible, but it’s always best to consult with your healthcare provider for personalized advice. They can ensure that your body has fully recovered and can guide you on the best course of action based on your individual circumstances.

Why Choose Rosh Maternal & Fetal Medicine for Recurrent Pregnancy Loss?

At Rosh Maternal & Fetal Medicine, we understand how difficult it can be to experience pregnancy loss, especially when it happens repeatedly. Our specialists are experienced in diagnosing and treating recurrent pregnancy loss, offering a range of services to address the underlying causes.

Our key benefits include:

  • Comprehensive Care: From advanced diagnostic testing to personalized treatment plans, we cover all aspects of your reproductive health.
  • Expert Specialists: Led by Dr. Daniel F. Roshan, our team is highly skilled in handling high-risk pregnancies and recurrent pregnancy loss.
  • State-of-the-Art Technology: We use the latest 3D/4D ultrasound and other imaging technologies to monitor and support your pregnancy.
  • Compassionate Support: We know the emotional toll that pregnancy loss can take, and we offer counseling and support throughout your fertility journey.

If you’ve experienced multiple miscarriages at 6-8 weeks or are concerned about your pregnancy health, schedule a consultation with one of our specialists. Together, we can explore the best path forward to help you achieve a healthy pregnancy.

Disclaimer: All information in this post should not be taken as medical advice. Patients should contact their healthcare provider before making any health decisions.